2-Amino-5-methoxypyridine → HCID 68719554, compound

Participants

Reaction Conditions

Reaction Steps

1.46 g (corresponding to 4.28 mmol) of 2-bromo-4′-hydroxy-3′-iodoacetophenone and 584 mg (corresponding to 4.71 mmol) of 2-amino-5-methoxypyridine were dissolved in 30 mL of acetonitrile. The resulting solution was heated under reflux in an oil bath at 110° C. for 2.5 hours. After the completion of the reaction, the reaction solution was cooled down to room temperature, and precipitates were filtered and recovered. The precipitates were washed with acetonitrile and dried under reduced pressure. The resulting crude crystals were suspended in a mixed solution of 3.0 mL of water and 1.0 mL of methanol. Then, about 10 mL of a saturated sodium hydrogencarbonate solution was added thereto, and the mixture was sonicated for 5 minutes using an ultrasonic washing machine. Precipitates were filtered and recovered from the resulting mixture, sufficiently washed with water, and dried under reduced pressure, to obtain 812 mg (corresponding to 2.22 mmol) of 2-(4′-hydroxy-3′-iodophenyl)-6-methoxyimidazo[1,2-a]pyridine (FIG. 5, Step 1).

Provenance & Evidence