Potassium Carbonate → HCID 74819772, compound

Participants

Reaction Conditions

Reaction Steps

366 mg (corresponding to 1.00 mmol) of 2-(4′-hydroxy-3′-iodophenyl)-6-methoxyimidazo[1,2-a]pyridine that was sufficiently dried to remove moisture was dissolved in 10.0 mL of N,N-dimethylformamide, and 415 mg (corresponding to 3.00 mmol) of potassium carbonate was added thereto. The mixture was supplemented with 327 mg (corresponding to 1.50 mmol) of 1-fluoro-2-paratoluenesulfonyloxyethane, and then the solution was stirred at 90° C. for 2 hours. After the completion of the reaction, a saturated aqueous ammonium chloride solution was added thereto, and extracted three times with ethyl acetate. The combined ethyl acetate layers were washed with water and a saturated sodium chloride solution, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The resulting crude product was purified by silica gel column chromatography (elution solvent: hexane/ethyl acetate=½), to obtain 381 mg (corresponding to 0.924 mmol) of 2-[4′-(2″-fluoroethoxy)-3′-iodophenyl]-6-methoxyimidazo[1,2-a]pyridine (FIG. 5, Step 2).

Provenance & Evidence