Water → HCID 68718916, compound

Participants

Reaction Steps

200 mg (corresponding to 0.274 mmol) of 2-[4′-(2″-t-butyldiphenylsiloxyethoxy)-2′-methoxyphenyl]-6-iodoimidazo[1,2-a]pyridine was dissolved in 2.0 mL of tetrahydrofuran, and 0.33 mL of a 1.0 mol/L tetrahydrofuran solution of tetrabutylammoniumfluoride was added thereto. After the reaction mixture was stirred at room temperature for 4 hours, an aqueous sodium hydrogencarbonate solution was added followed by addition of 5.0 mL of water and 1.0 mL of acetonitrile to filter precipitates. The filtered precipitates were washed with water and acetonitrile in this order to obtain 103 mg (corresponding to 0.251 mmol) of 2-[4′-(2″-hydroxyethoxy)-2′-methoxyphenyl]-6-iodoimidazo[1,2-a]pyridine (FIG. 7, Step 6).

Provenance & Evidence