Potassium Carbonate → HCID 10411957, compound

Participants

Reaction Steps

6-[1-(acetoxyacetyl)piperidin-3-yloxy]-4-(3-chloro-2-fluoroanilino)-7-methoxyquinazoline (930 mg, 1.85 mmol) (prepared as described in Example 27) and potassium carbonate (385 mg, 2.79 mmol) in methanol (50 ml) was stirred at room temperature for 3 hours. The solvent was evaporated under vacuum and the residue purified by column chromatography eluting with methylene chloride/methanol (saturated with ammonia) (92/8). The fractions containing the expected product were combined and evaporated. The residue was triturated with acetone, filtered and dried to give the title product (574 mg, 67%);

Provenance & Evidence