Hydrochloric Acid → HCID 68520254, compound

Participants

Reaction Steps

4-(3-chloro-2-fluoroanilino)-6-[(3S)-1-(tert-butoxycarbonyl)pyrrolidin-3-yloxy]-7-methoxyquinazoline was reacted with hydrogen chloride (4.0M in 1,4-dioxane) to give 4-(3-chloro-2-fluoroanilino)-6-[(3S)-pyrrolidin-3-yloxy]-7-methoxyquinazoline hydrochloride (1.94 g, 93%); 1H NMR Spectrum: (DMSO d) 2.18-2.28 (m, 1H); 135-145 (m, 1H); 3.27-3.46 (m, 3H); 3.73-3.82 (m, 1H); 3.99 (s, 3H); 5.41-5.47 (m, 1H); 7.31-7.37 (m, 1H); 7.44 (s, 1H); 7.47-7.54 (m, 1H); 7.58-7.64 (m, 1H); 8.66 (s, 1H); 8.80 (s, 1H); 9.42 (bs, 1H); 9.61 (bs, 1H); 12.24 (bs, 1H); Mass Spectrum: (M−H)+389.

Provenance & Evidence