Methanesulfonyl chloride → HCID 60036693, compound

Participants

Reaction Steps

Using a similar process to that described in Example 29, 4-(3-chloro-2-fluoroanilino)-7-methoxy-6-[(2R)-pyrrolidin-2-ylmethoxy]quinazoline hydrochloride (300 mg) was reacted with methane sulfonyl chloride to give the title product (250 mg, 76%); 1H NMR Spectrum: (DMSO d6) 1.88-2.12 (m, 4H); 2.99 (s, 3H); 3.30-3.34 (m, 2H); 3.94 (s, 3H); 4.02 (m, 1H); 4.15 (m, 2H); 7.15-7.30 (m, 2H); 7.40-7.55 (m, 2H); 7.81 (s, 1H); 8.36 (s, 1H); 9.62 (s, 1H); Mass Spectrum: (M+H)+ 481.

Provenance & Evidence