3-Chloro-2-fluoroaniline → HCID 68521248, compound

Participants

Reaction Steps

4-chloro-7-methoxy-6-{[(2R)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl]methoxy}quinazoline was reacted with 3-chloro-2-fluoroaniline to give 4-(3-chloro-2-fluoroanilino)-7-methoxy-6-{[(2R)-pyrrolidin-2-yl]methoxy}quinazoline hydrochloride (5.3 g 100%); 1H NMR Spectrum: (DMSO d6) 1.70-1.84 (m, 1H); 1.87-1.97 (m, 1H); 1.99-2.08 (m, 1H); 2.17-2.28 (m, 1H); 3.18-3.27 (m, 2H); 3.98-4.10 (m, 4H); 4.45-4.57 (m, 2H); 7.32-7.38 (m, 1H); 7.47 (s, 1H); 7.49-7.55 (m, 1H); 7.59-7.65 (m, 1H); 8.66 (s, 1H); 8.81 (s, 1H); 9.30 (bs, 1H); 9.67 (bs, 1H); 12.09 (bs, 1H); Mass Spectrum: (M−H)− 401.

Provenance & Evidence