Sodium Hydroxide → HCID 59371216, compound

Participants

Reaction Steps

2M NaOH (1 ml, 2 mmol) was added to a stirred solution of 4-(3-chloro-2-fluoroanilino)-6-[(2RS,4R)-1-methyl-2-(methoxycarbonyl)pyrrolidin-4-yloxy]-7-methoxyquinazoline (250 mg, 0.54 mmol) in methanol (5 ml) and the mixture stirred at room temperature for 18 hours. The reaction mixture was evaporated and the residues re-dissolved in water (50 ml). This was then washed with ethyl acetate (25 ml) and the aqueous phase evaporated to dryness and azeotroped with toluene. The residues were triturated with methylene chloride/methanol (9/1) (25 ml), filtered and the liquors evaporated to give 4-(3-chloro-2-fluoroanilino)-6-[(2RS,4R)-1-methyl-2-carboxypyrrolidin-4-yloxy]-7-methoxyquinazoline as a white foam (155 mg); Mass Spectrum: (M+H)+ 447,

Provenance & Evidence