HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1948959Generated: October 31, 2026
Chloroacetyl chloride → 6-[1-(Chloroacetyl)piperidin-3-yloxy]4-(3-chloro-2-fluoroanilino)-7-methoxyquinazoline
https://huagongshe.com/reaction/1948959
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Chloroacetyl chloride | HCID 6577 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 4-(3-Chloro-2-fluoroanilino)-7-methoxy-6-(piperidin-3-yloxy)quinazoline dihydrochloride | HCID 68522457 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 6-[1-(Chloroacetyl)piperidin-3-yloxy]4-(3-chloro-2-fluoroanilino)-7-methoxyquinazoline | HCID 68523638 | — |
Reaction Steps
Chloroacetyl chloride (89 μl) was added to a solution of 4-(3-chloro-2-fluoroanilino)-7-methoxy-6-(piperidin-3-yloxy)quinazoline dihydrochloride (469 mg; prepared as described in Example 45) and diisopropylethylamine (700 μl) in methylene chloride (15 ml) that was cooled to 0° C. The mixture was stirred at room temperature for 2 hours to give 6-[1-(chloroacetyl)piperidin-3-yloxy]-4-(3-chloro-2-fluoroanilino)-7-methoxyquinazoline; Mass Spectrum: (M+H)+ 479.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08399667B2 |
|---|
| Source dataset | uspto-grants-2013_03 |
|---|
| ORD ID | ord-112612c967624e0a8e0133118d539d7c |
|---|
| Source note | uspto-grants-2013_03 |
|---|
