Chloroacetyl chloride → HCID 68521521, compound

Participants

Reaction Conditions

Reaction Steps

Chloroacetyl chloride (66 μl) was added to a solution of 4-(3-chloro-2-fluoroanilino)-7-methoxy-6-[(3S)-piperidin-3-yloxy]quinazoline hydrochloride (350 mg; prepared according to Example 49) and diisopropylethylamine (522 μl) in methylene chloride (10 ml) that was cooled to 0° C. and the mixture was stirred at room temperature for 30 mins. Pyrrolidine (0.37 ml) was added, and the solution stirred for 1 hour before being purified by flash column chromatography eluting with methylene chloride/methanol (containing ammonia 7N) (97/3). The fractions containing the expected product were combined and evaporated to give a foam. This foam was dissolved in methylene chloride (5 ml) and crystallised by the addition of isohexane (50 ml) to give the title product (0.206 g); 1H NMR Spectrum: (DMSO d6, 100° C.) 1.50-1.72 (m, 5H), 1.83-1.95 (m, 2H), 2.08-2.18 (m, 1H), 2.40-2.58 (m, 4H), 3.18 (d, 1H), 3.37 (d, 1H), 3.48-3.56 (m, 1H), 3.58-3.64 (m, 1H), 3.68-3.77 (m, 1H), 3.89-3.93 (m, 1H), 3.95 (s, 3H), 4.51-4.59 (m, 1H), 7.23-7.31 (m, 2H), 7.40-7.48 (m, 1H), 7.57-7.64 (m, 1H), 7.90 (s, 1H), 8.41 (br s, 1H), 9.25 (br s, 1H); Mass Spectrum: (M+H)+ 514.

Provenance & Evidence