Acetic Acid → 4-Anilinopiperidine

Participants

Reaction Conditions

Reaction Steps

In a three neck round bottom flask equipped with mechanical stirrer and water condenser, 15.36 gm (0.10 moles) of 4-piperidone hydrochloride monohydrate and 20.95 gm (0.255 moles) of aniline was added. To this mixture, 26.14 gm (0.40 moles) of zinc and 120 gm (2.00 moles) of 90% acetic acid were added. The reaction mixture was stirred at room temperature for 12 hrs and at 50 to 70° C. for 12 hrs. Water was then added to the reaction mixture and filtered. Crushed ice was added to the filtrate and was neutralized with excess of aqueous sodium hydroxide solution. The crude 4-anilinopiperidine was obtained by filtration.

Provenance & Evidence