Acetic Acid → 4-Anilinopiperidine

Participants

Reaction Conditions

Reaction Steps

In a three neck round bottom flask equipped with mechanical stirrer and water condenser, 15.36 gm (0.10 moles) of 4-piperidone hydrochloride monohydrate and 16.43 gm (0.2 moles) of aniline were added. To this mixture, 130 gm (2.0 moles) of zinc and 120 gm (2.00 moles) of 90% acetic acid were added. The reaction mixture was stirred at room temperature for 24 hrs and at 50 to 70° C. for 24 hrs. Water was then added to the reaction mixture and filtered. Crushed ice was added to the filtrate and was neutralized with excess of aqueous sodium hydroxide solution. The crude 4-anilinopiperidine was obtained by filtration.

Provenance & Evidence