3-Pyridinemethanamine → HCID 68576902, compound

HRID 1949027Notes

Reaction equation

Cl[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([NH:12][CH2:13][C:14]1[CH:19]=[CH:18][C:17]([F:20])=[CH:16][C:15]=1[O:21][CH3:22])[CH:6]=[C:5]2[NH:23][CH2:24][CH2:25][O:26][CH3:27].[N:28]1[CH:33]=[CH:32][CH:31]=[C:30]([CH2:34][NH2:35])[CH:29]=1>>[F:20][C:17]1[CH:18]=[CH:19][C:14]([CH2:13][NH:12][C:7]2[CH:6]=[C:5]([NH:23][CH2:24][CH2:25][O:26][CH3:27])[C:4]3[C:9](=[CH:10][CH:11]=[C:2]([NH:35][CH2:34][C:30]4[CH:29]=[N:28][CH:33]=[CH:32][CH:31]=4)[CH:3]=3)[N:8]=2)=[C:15]([O:21][CH3:22])[CH:16]=1

Participants

Reactant 2

HCID 310183-Pyridinemethanamine

HCID 68574928HCID 68574928, compound

Product 1

HCID 68576902HCID 68576902, compound

Procedure

The title compound, MS: m/e=462.5 (M+H+), was prepared in accordance with the general method of example 30, step D from 6-chloro-N2-(4-fluoro-2-methoxy-benzyl)-N4-(2-methoxy-ethyl)-quinoline-2,4-diamine and 3-picolylamine.

Sources & evidence

ORD record: ord-5dc9b8595e0b40b693cf3563172f43a0
Source dataset: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08399674B2

Reaction notes

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