2-(3-Aminophenyl)ethan-1-ol → HCID 25235755, compound

HRID 1949068Notes

Reaction equation

HRID 1949068 reaction equation
Br[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([NH:12][CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[O:20][CH3:21])[CH:6]=[CH:5]2.[OH:22][CH2:23][CH2:24][C:25]1[CH:26]=[C:27]([CH:29]=[CH:30][CH:31]=1)[NH2:28]>>[CH3:21][O:20][C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=1[CH2:13][NH:12][C:7]1[CH:6]=[CH:5][C:4]2[C:9](=[CH:10][CH:11]=[C:2]([NH:28][C:27]3[CH:26]=[C:25]([CH2:24][CH2:23][OH:22])[CH:31]=[CH:30][CH:29]=3)[CH:3]=2)[N:8]=1

Participants

3

Reactant 2

HCID 149389872-(3-Aminophenyl)ethan-1-olHCID 68574436HCID 68574436, compound

Product 1

HCID 25235755HCID 25235755, compound

Procedure

The title compound, yellow oil, MS: m/e=400.3 (M+H+), was prepared in accordance with the general method of example 84 from (6-bromo-quinolin-2-yl)-(2-methoxy-benzyl)-amine (see example 2, step A) and commercially available 3-(2-hydroxyethyl)-aniline.

Sources & evidence

ORD record
ord-e93a609b836249e3becf01e012690335
Source dataset
uspto-grants-2013_03
Patent number
US08399674B2

Reaction notes

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