HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1949075Generated: October 30, 2026
Potassium Hydroxide → 1-Benzyl-4-hydroxy-piperidine-4-carboxylic acid methyl-(4-trifluoromethoxy-phenyl)-amide
https://huagongshe.com/reaction/1949075
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | Acetic acid 1-benzyl-4-[methyl-(4-trifluoromethoxy-phenyl)-carbamoyl]-piperidin-4-yl ester | HCID 58129329 | — |
| Solvent | Potassium bisulfate | HCID 516920 | — |
| Product | 1-Benzyl-4-hydroxy-piperidine-4-carboxylic acid methyl-(4-trifluoromethoxy-phenyl)-amide | HCID 58129342 | 59.1% |
Reaction Steps
A mixture of 0.782 g (1.7 mmol) acetic acid 1-benzyl-4-[methyl-(4-trifluoromethoxy-phenyl)-carbamoyl]-piperidin-4-yl ester and excess KOH 5M was heated to 70° C. The mixture was diluted with KHSO4 1N aq. and extracted with ethyl acetate. the combined organic fractions were dried with MgSO4 and evaporated. The residue was purified by preparative HPLC on reversed phase eluting with a gradient formed from acetonitrile, water and HCOOH. The product containing fractions were evaporated to yield 0.41 g (58%) of the title compound. MS (m/e): 409.1 [(M+H)+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08399676B2 |
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| Source dataset | uspto-grants-2013_03 |
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| ORD ID | ord-f4b901d5562748b393dd6ee6125e385d |
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| Source note | uspto-grants-2013_03 |
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