HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-Amino-1-(toluene-4-sulfonyl)-piperidine-4-carboxylic acid (4-ethyl-phenyl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-Ethylaniline | HCID 11504 | — |
| Reactant | HCID 50913226 | HCID 50913226 | — |
| Reactant | 4-tert-Butoxycarbonylamino-1-(toluene-4-sulfonyl)-piperidine-4-carboxylic acid | HCID 66921307 | — |
| Product | 4-Amino-1-(toluene-4-sulfonyl)-piperidine-4-carboxylic acid (4-ethyl-phenyl)-amide | HCID 66921364 | — |
Reaction Steps
In analogy to the procedure described for the synthesis of 4-Amino-1-(toluene-4-sulfonyl)-piperidine-4-carboxylic acid (4-tert-butyl-phenyl)-amide; hydrochloride (example 77) the title compound was prepared from 4-tert-Butoxycarbonylamino-1-(toluene-4-sulfonyl)-piperidine-4-carboxylic acid (example 77, step 2) and 4-ethyl-aniline with subsequent cleavage of the Boc group with HCl. The compound was purified with preparative HPLC on reversed phase. MS (m/e): 402.4 [(M+H)+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08399676B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-d4fbde1036294bc1b3a133ba2287b9cc |
| Source note | uspto-grants-2013_03 |