3-(Trifluoromethyl)aniline → HCID 50913375, compound

Participants

Reaction Steps

In analogy to the procedure of the synthesis of [4-(4-tert-Butyl-phenylcarbamoyl)-1-(toluene-4-sulfonyl)-piperidin-4-yl]-carbamic acid tert-butyl ester (example 77, step 2) the title compound was prepared from 4-tert-Butoxycarbonylamino-1-(2-chloro-benzenesulfonyl)-piperidine-4-carboxylic acid through amide coupling with 3-trifluoromethyl-aniline (commercially available) followed by the removal of the protecting group with HCl in dioxane to afford the title compound after purification with preparative HPLC on reversed phase eluting with a gradient formed from acetonitrile, water and NEt3. MS (m/e): 462.1 [(M+H)+].

Provenance & Evidence