反应详情

A mixture of 2.84 g (6 mmol) 4-tert-Butoxycarbonylamino-4-(4-isopropyl-phenylcarbamoyl)-piperidine-1-carboxylic acid benzyl ester (example 82, step 1) in 80 mL methanol was hydrogenated with H2 over Pd/C (10%) for 2 h at room temperature. The mixture was filtered off and evaporated to dryness to yield 1.94 g (94%) of the title compound as off-white crystals. MS (m/e): 362.4 [(M+H)+].

1. filtrationThe mixture was filtered off
2. customevaporated to dryness