HCID 66921313, compound → HCID 66921320, compound

Participants

Reaction Steps

A solution of 2.86 g (5.9 mmol) 4-tert-Butoxycarbonylamino-4-(4-ethyl-phenylcarbamoyl)-piperidine-1-carboxylic acid benzyl ester (example 132, step 1) in 70 mL methanol was hydrogenated over 290 mg Pd/C (10%) with H2 (1 bar) for 2 h at room temperature. After filtration the filtrate was evaporated to dryness to yield after drying under high vacuum 2.05 g (99%) of the title compound as off-white solid. MS (m/e): 348.3 [(M+H)+].

Provenance & Evidence