3-Cyano-4-fluorophenylhydrazine hydrochloride → HCID 58277386, compound

HRID 1949220Notes

Reaction equation

HRID 1949220 reaction equation
Cl.[C:2]([C:4]1[CH:5]=[C:6]([NH:11][NH2:12])[CH:7]=[CH:8][C:9]=1[F:10])#[N:3].ClC1C=C(N2[C:25]([C:26]3[CH:31]=[C:30](F)[CH:29]=[C:28]([Cl:33])[CH:27]=3)=[CH:24][C:23]([C:34]([O:36][CH2:37][CH3:38])=[O:35])=N2)C=CC=1F>>[Cl:33][C:28]1[CH:27]=[C:26]([C:25]2[N:11]([C:6]3[CH:7]=[CH:8][C:9]([F:10])=[C:4]([C:2]#[N:3])[CH:5]=3)[N:12]=[C:23]([C:34]([O:36][CH2:37][CH3:38])=[O:35])[CH:24]=2)[CH:31]=[CH:30][CH:29]=1

Participants

3

Reactant 2

HCID 219368473-Cyano-4-fluorophenylhydrazine hydrochlorideHCID 58277311HCID 58277311, compound

Product 1

HCID 58277386HCID 58277386, compound

Procedure

The preparation of the title compound takes place starting from the compound of Example 3A and 3-cyano-4-fluorophenylhydrazine hydrochloride in analogy to the synthesis of the compound of Example 21A. 0.76 g of the title compound with 46% purity (23% of theory) are obtained.

Sources & evidence

ORD record
ord-71ede70e449f4b038aa92b794ce4c872
Source dataset
uspto-grants-2013_03
Patent number
US08399682B2

Reaction notes

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