Lithium Hydroxide → HCID 58277393, compound

Participants

Reaction Conditions

Reaction Steps

23.0 g (66.7 mmol) of the compound of Example 35A are provided in 100 ml of 1,4-dioxane, 100 ml (200 mmol) of a 2N solution of lithium hydroxide in water are added, and the mixture is stirred at 50° C. for 2 h. The mixture is concentrated, a conc. aqueous hydrogen chloride solution is subsequently added until the pH is acidic, the mixture is extracted with dichloromethane, and the organic phase is dried over magnesium sulfate, filtered and concentrated. The residue is stirred in a little diethyl ether, collected by filtration and dried under high vacuum. 17.8 g (84% of theory) of the title compound are obtained.

Provenance & Evidence