Lithium Hydroxide → HCID 58277279, compound

Participants

Reaction Conditions

Reaction Steps

4.50 g (11.9 mmol) of the compound of Example 37A are provided in 107 ml of 1,4-dioxane, 107 ml (214 mmol) of a 2N solution of lithium hydroxide in water are added, and the mixture is stirred at 70° C. for 2 h. The mixture is concentrated, a 2N aqueous hydrogen chloride solution is subsequently added to the residue until the pH is acidic, the mixture is extracted with dichloromethane, and the organic phase is dried over magnesium sulfate, filtered and concentrated. 4.11 g (99% of theory) of the title compound are obtained.

Provenance & Evidence