Lithium Hydroxide → HCID 58277293, compound

Participants

Reaction Conditions

Reaction Steps

4.75 g (12.0 mmol) of the compound of Example 55A are provided in 108 ml of 1,4-dioxane, 108 ml (216 mmol) of a 2N solution of lithium hydroxide in water are added, and the mixture is stirred at 70° C. for 2 h. The mixture is concentrated, a conc. aqueous hydrogen chloride solution is subsequently added to the residue until the pH is acidic, the mixture is extracted with dichloromethane, and the organic phase is dried over magnesium sulfate, filtered and concentrated. 4.40 g (100% of theory) of the title compound are obtained.

Provenance & Evidence