HCID 58277326, compound → HCID 58277286, compound

HRID 1949264Notes

Reaction equation

HRID 1949264 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[N:13]([C:14]3[CH:19]=[CH:18][CH:17]=[C:16]([C:20]#[N:21])[CH:15]=3)[N:12]=[C:11]([C:22]([O:24]CC)=[O:23])[CH:10]=2)[CH:5]=[CH:6][C:7]=1[F:8].ClC1C=C(N2C(C3C=C(F)C=C(Cl)C=3)=CC(C(O)=O)=N2)C=CC=1F>>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[N:13]([C:14]3[CH:19]=[CH:18][CH:17]=[C:16]([C:20]#[N:21])[CH:15]=3)[N:12]=[C:11]([C:22]([OH:24])=[O:23])[CH:10]=2)[CH:5]=[CH:6][C:7]=1[F:8]

Participants

3

Reactant 2

HCID 58277326HCID 58277326, compoundHCID 58277336HCID 58277336, compound

Product 1

HCID 58277286HCID 58277286, compound

Procedure

The preparation of the title compound takes place starting from the compound of Example 59A in analogy to the synthesis of the compound of Example 71A. 21 mg of the title compound with 83% purity (64% of theory) are obtained.

Sources & evidence

ORD record
ord-0ce35ff7f9f84e97b7820a84db43df37
Source dataset
uspto-grants-2013_03
Patent number
US08399682B2

Reaction notes

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