HCID 58277326, compound → HCID 58277309, compound

HRID 1949265Notes

Reaction equation

HRID 1949265 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[N:12]([C:13]3[CH:18]=[CH:17][C:16]([F:19])=[C:15]([C:20]#[N:21])[CH:14]=3)[N:11]=[C:10]([C:22]([O:24]CC)=[O:23])[CH:9]=2)[CH:5]=[CH:6][CH:7]=1.ClC1C=C(N2C(C3C=C(F)C=C(Cl)C=3)=CC(C(O)=O)=N2)C=CC=1F>>[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[N:12]([C:13]3[CH:18]=[CH:17][C:16]([F:19])=[C:15]([C:20]#[N:21])[CH:14]=3)[N:11]=[C:10]([C:22]([OH:24])=[O:23])[CH:9]=2)[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 58277326HCID 58277326, compoundHCID 58277386HCID 58277386, compound

Product 1

HCID 58277309HCID 58277309, compound

Procedure

The preparation of the title compound takes place starting from the compound of Example 60A in analogy to the synthesis of the compound of Example 71A but with stiffing for 6 hours. 672 mg of the title compound with 61% purity are obtained.

Sources & evidence

ORD record
ord-8f656a9560d445a6b8182b1b2e329d6f
Source dataset
uspto-grants-2013_03
Patent number
US08399682B2

Reaction notes

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