HCID 58277326, compound → HCID 58277320, compound

HRID 1949266Notes

Reaction equation

HRID 1949266 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[N:12]([C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([C:19]#[N:20])[CH:14]=3)[N:11]=[C:10]([C:21]([O:23]CC)=[O:22])[CH:9]=2)[CH:5]=[CH:6][CH:7]=1.ClC1C=C(N2C(C3C=C(F)C=C(Cl)C=3)=CC(C(O)=O)=N2)C=CC=1F>>[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[N:12]([C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([C:19]#[N:20])[CH:14]=3)[N:11]=[C:10]([C:21]([OH:23])=[O:22])[CH:9]=2)[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 58277326HCID 58277326, compoundHCID 58277449HCID 58277449, compound

Product 1

HCID 58277320HCID 58277320, compound

Procedure

The preparation of the title compound takes place starting from the compound of Example 61A in analogy to the synthesis of the compound of Example 71A but with stiffing for 6 hours. 470 mg of the title compound with 77% purity are obtained.

Sources & evidence

ORD record
ord-855dab1d5e0f4b0485e023a7bc47eb0b
Source dataset
uspto-grants-2013_03
Patent number
US08399682B2

Reaction notes

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