HCID 58277314, compound → HCID 58277377, compound

HRID 1949268Notes

Reaction equation

HRID 1949268 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]([N:10]2[C:14]([C:15]3[CH:20]=[CH:19][CH:18]=[C:17]([C:21]#[N:22])[CH:16]=3)=[CH:13][C:12]([C:23]([O:25]CC)=[O:24])=[N:11]2)[CH:6]=[CH:7][C:8]=1[F:9])#[N:2].ClC1C=C(N2C(C3C=C(F)C=C(Cl)C=3)=CC(C(O)=O)=N2)C=CC=1F>>[C:1]([C:3]1[CH:4]=[C:5]([N:10]2[C:14]([C:15]3[CH:20]=[CH:19][CH:18]=[C:17]([C:21]#[N:22])[CH:16]=3)=[CH:13][C:12]([C:23]([OH:25])=[O:24])=[N:11]2)[CH:6]=[CH:7][C:8]=1[F:9])#[N:2]

Participants

3

Reactant 2

HCID 58277314HCID 58277314, compoundHCID 58277326HCID 58277326, compound

Product 1

HCID 58277377HCID 58277377, compound

Procedure

The preparation of the title compound takes place starting from the compound of Example 63A in analogy to the synthesis of the compound of Example 71A but with stiffing for 6 hours. 430 mg of the title compound with 43% purity are obtained.

Sources & evidence

ORD record
ord-d19e40c13895423b86c7e5e88a5c62f3
Source dataset
uspto-grants-2013_03
Patent number
US08399682B2

Reaction notes

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