HCID 58277326, compound → HCID 58277339, compound

HRID 1949269Notes

Reaction equation

HRID 1949269 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[N:13]([C:14]3[CH:19]=[CH:18][CH:17]=[C:16]([C:20]#[N:21])[CH:15]=3)[N:12]=[C:11]([C:22]([O:24]CC)=[O:23])[CH:10]=2)[CH:5]=[C:6]([F:8])[CH:7]=1.ClC1C=C(N2C(C3C=C(F)C=C(Cl)C=3)=CC(C(O)=O)=N2)C=CC=1F>>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[N:13]([C:14]3[CH:19]=[CH:18][CH:17]=[C:16]([C:20]#[N:21])[CH:15]=3)[N:12]=[C:11]([C:22]([OH:24])=[O:23])[CH:10]=2)[CH:5]=[C:6]([F:8])[CH:7]=1

Participants

3

Reactant 2

HCID 58277326HCID 58277326, compoundHCID 58277372HCID 58277372, compound

Product 1

HCID 58277339HCID 58277339, compound

Procedure

The preparation of the title compound takes place starting from the compound of Example 64A in analogy to the synthesis of the compound of Example 71A but with stiffing for 6 hours. 1.21 g of the title compound with 53% purity are obtained.

Sources & evidence

ORD record
ord-888a71add88e4672b485368245f32d3f
Source dataset
uspto-grants-2013_03
Patent number
US08399682B2

Reaction notes

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