HCID 58277326, compound → HCID 58277351, compound

HRID 1949270Notes

Reaction equation

HRID 1949270 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[N:13]([C:14]3[CH:19]=[CH:18][C:17]([F:20])=[C:16]([C:21]#[N:22])[CH:15]=3)[N:12]=[C:11]([C:23]([O:25]CC)=[O:24])[CH:10]=2)[CH:5]=[C:6]([F:8])[CH:7]=1.ClC1C=C(N2C(C3C=C(F)C=C(Cl)C=3)=CC(C(O)=O)=N2)C=CC=1F>>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[N:13]([C:14]3[CH:19]=[CH:18][C:17]([F:20])=[C:16]([C:21]#[N:22])[CH:15]=3)[N:12]=[C:11]([C:23]([OH:25])=[O:24])[CH:10]=2)[CH:5]=[C:6]([F:8])[CH:7]=1

Participants

3

Reactant 2

HCID 58277326HCID 58277326, compoundHCID 58277406HCID 58277406, compound

Product 1

HCID 58277351HCID 58277351, compound

Procedure

The preparation of the title compound takes place starting from the compound of Example 65A in analogy to the synthesis of the compound of Example 71A but with stiffing for 6 hours. 1.88 g of the title compound with 64% purity are obtained.

Sources & evidence

ORD record
ord-b8ed80fdea6e4b50af4036010dc27a76
Source dataset
uspto-grants-2013_03
Patent number
US08399682B2

Reaction notes

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