HCID 58277326, compound → HCID 58277461, compound

HRID 1949272Notes

Reaction equation

HRID 1949272 reaction equation
C([O:4][CH2:5][CH2:6][CH2:7][O:8][C:9]1[CH:10]=[C:11]([C:15]2[N:19]([C:20]3[CH:25]=[CH:24][CH:23]=[C:22]([Cl:26])[CH:21]=3)[N:18]=[C:17]([C:27]([O:29]CC)=[O:28])[CH:16]=2)[CH:12]=[CH:13][CH:14]=1)(=O)C.ClC1C=C(N2C(C3C=C(F)C=C(Cl)C=3)=CC(C(O)=O)=N2)C=CC=1F>>[Cl:26][C:22]1[CH:21]=[C:20]([N:19]2[C:15]([C:11]3[CH:12]=[CH:13][CH:14]=[C:9]([O:8][CH2:7][CH2:6][CH2:5][OH:4])[CH:10]=3)=[CH:16][C:17]([C:27]([OH:29])=[O:28])=[N:18]2)[CH:25]=[CH:24][CH:23]=1

Participants

3

Reactant 2

HCID 58277326HCID 58277326, compoundHCID 58277434HCID 58277434, compound

Product 1

HCID 58277461HCID 58277461, compound

Procedure

The preparation of the title compound takes place starting from the compound of Example 67A in analogy to the synthesis of the compound of Example 71A. 99 mg of the title compound with 65% purity (70% of theory) are obtained.

Sources & evidence

ORD record
ord-43a6b14e29d546baac9f6b744560e40e
Source dataset
uspto-grants-2013_03
Patent number
US08399682B2

Reaction notes

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