Hydrochloric Acid → HCID 58277353, compound

Participants

Reaction Steps

20.0 ml of water and 453 mg (18.9 mmol) of lithium hydroxide are added to 700 mg (1.89 mmol) of the carboxylic ester of Example 130A in 60.0 ml of THF. The mixture is stirred at RT overnight and a 1N aqueous hydrogen chloride solution is subsequently added to the reaction solution. The mixture is extracted with dichloromethane, and the combined organic phases are dried over magnesium sulfate, filtered and concentrated in vacuo. The crude product is purified by preparative HPLC (RP18 column; mobile phase: acetonitrile/water gradient). 712 mg (89% of theory) of the title compound are obtained in 81% purity.

Provenance & Evidence