Hydrochloric Acid → HCID 58277275, compound

Participants

Reaction Steps

10.0 ml of water and 570 mg (23.8 mmol) of lithium hydroxide are added to 900 mg (1.78 mmol) of the carboxylic ester of Example 132A with 75% purity in 30.0 ml of THF. The mixture is stirred at RT for 5 h and a 1N aqueous hydrogen chloride solution is subsequently added to the reaction solution. The mixture is extracted with dichloromethane, and the combined organic phases are dried over magnesium sulfate, filtered and concentrated in vacuo. The crude product is purified by preparative HPLC (RP18 column; mobile phase: acetonitrile/water gradient). 527 mg (86% of theory) of the title compound are obtained.

Provenance & Evidence