Hydrochloric Acid → HCID 58277436, compound

Participants

Reaction Steps

15.0 ml of water and 797 mg of lithium hydroxide (33.3 mmol) are added to 1.20 g (3.00 mmol) of the carboxylic ester of Example 134A with 90% purity in 45.0 ml of THF. The mixture is stirred at RT for 5 h and a 1N aqueous hydrogen chloride solution is subsequently added to the reaction solution. The mixture is extracted with dichloromethane and the combined organic phases are dried over magnesium sulfate, filtered and concentrated in vacuo. The crude product is purified by preparative HPLC (RP18 column; mobile phase: acetonitrile/water gradient). 821 mg (82% of theory) of the title compound are obtained.

Provenance & Evidence