Dimethylamine → HCID 67153505, compound

Participants

Reaction Steps

49.6 mg (0.096 mmol) of the compound of Example 120A and 0.48 ml (0.96 mmol) of a 2M solution of dimethylamine in tetrahydrofuran are stirred in 3 ml of ethanol at 80° C. overnight. The reaction mixture is subsequently purified by preparative HPLC (RP18 column; mobile phase: acetonitrile/water gradient with the addition of 0.1% formic acid). 6.2 mg (23% of theory) of the title compound are obtained.

Provenance & Evidence