HCID 58277330, compound → HCID 58277274, compound

HRID 1949307Notes

Reaction equation

HRID 1949307 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[C:12]([C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([O:19][CH2:20][CH2:21][O:22][CH3:23])[CH:14]=3)=[CH:11][C:10]([C:24](O)=[O:25])=[N:9]2)[CH:5]=[CH:6][CH:7]=1.ClC1C=C(N2C(C3C=CC=C(OCCO)C=3)=CC(C([N:51]3[CH2:55][C:54](=[O:56])[NH:53][CH2:52]3)=O)=N2)C=CC=1>>[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[C:12]([C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([O:19][CH2:20][CH2:21][O:22][CH3:23])[CH:14]=3)=[CH:11][C:10]([C:24]([N:51]3[CH2:55][C:54](=[O:56])[NH:53][CH2:52]3)=[O:25])=[N:9]2)[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 58277330HCID 58277330, compoundHCID 58277360HCID 58277360, compound

Product 1

HCID 58277274HCID 58277274, compound

Procedure

The preparation of the title compound takes place starting from the compound of Example 117A in analogy to the synthesis of the compound of Example 23. In order to remove the 1,1′,1″-phosphoryltripyrrolidine the product is taken up in a little tetrahydrofuran, water is added to the mixture until a precipitate forms, the tetrahydrofuran is removed in vacuo, and the precipitate is collected by suction filtration, and dried under high vacuum. 10 mg (19% of theory) of the title compound are obtained.

Workup

  1. customIn order to remove the 1,1′,1″-phosphoryltripyrrolidine the product
  2. additionis added to the mixture until a precipitate forms
  3. customthe tetrahydrofuran is removed in vacuo
  4. filtrationthe precipitate is collected by suction filtration
  5. customdried under high vacuum

Sources & evidence

ORD record
ord-e6e004ac258d477c8b23942b08099281
Source dataset
uspto-grants-2013_03
Patent number
US08399682B2

Reaction notes

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