1187917-12-9 → HCID 44230249, compound

HRID 1949317Notes

Reaction equation

HRID 1949317 reaction equation
[F:1][C:2]([F:29])([F:28])[C:3]1[CH:4]=[C:5]([C:13]2[N:17]([C:18]3[CH:23]=[CH:22][CH:21]=[C:20]([Cl:24])[CH:19]=3)[N:16]=[C:15]([C:25]([OH:27])=O)[CH:14]=2)[CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1.ClC1C=C(N2C(C3C=C(F)C=C(Cl)C=3)=CC(C([N:53]3[CH2:57][C:56](=[O:58])[NH:55][CH2:54]3)=O)=N2)C=CC=1F>>[F:11][C:9]([F:12])([F:10])[C:7]1[CH:6]=[C:5]([C:13]2[N:17]([C:18]3[CH:23]=[CH:22][CH:21]=[C:20]([Cl:24])[CH:19]=3)[N:16]=[C:15]([C:25]([N:53]3[CH2:57][C:56](=[O:58])[NH:55][CH2:54]3)=[O:27])[CH:14]=2)[CH:4]=[C:3]([C:2]([F:1])([F:28])[F:29])[CH:8]=1

Participants

3

Reactant 2

HCID 442301811187917-12-9HCID 58277463HCID 58277463, compound

Product 1

HCID 44230249HCID 44230249, compound

Procedure

The preparation of the title compound takes place starting from the compound of Example 103A in analogy to the synthesis of the compound of Example 1. 26 mg (72% of theory) of the title compound are obtained.

Sources & evidence

ORD record
ord-2e95d4dc03de4e4384b03bb356c1604c
Source dataset
uspto-grants-2013_03
Patent number
US08399682B2

Reaction notes

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