HCID 58277286, compound → HCID 58277438, compound

HRID 1949322Notes

Reaction equation

HRID 1949322 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[N:13]([C:14]3[CH:19]=[CH:18][CH:17]=[C:16]([C:20]#[N:21])[CH:15]=3)[N:12]=[C:11]([C:22](O)=[O:23])[CH:10]=2)[CH:5]=[CH:6][C:7]=1[F:8].ClC1C=C(N2C(C3C=CC=C(OCCO)C=3)=CC(C([N:49]3[CH2:53][C:52](=[O:54])[NH:51][CH2:50]3)=O)=N2)C=CC=1>C(O)=O>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[N:13]([C:14]3[CH:19]=[CH:18][CH:17]=[C:16]([C:20]#[N:21])[CH:15]=3)[N:12]=[C:11]([C:22]([N:49]3[CH2:53][C:52](=[O:54])[NH:51][CH2:50]3)=[O:23])[CH:10]=2)[CH:5]=[CH:6][C:7]=1[F:8]

Participants

4

Reactant 2

HCID 58277286HCID 58277286, compoundHCID 58277360HCID 58277360, compound

Product 1

HCID 58277438HCID 58277438, compound

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

The preparation of the title compound takes place starting from the compound of Example 108A with the addition of 0.1% formic acid in the preparative HPLC in analogy to the synthesis of the compound of Example 23. 8 mg (35% of theory) of the title compound are obtained.

Sources & evidence

ORD record
ord-29d58fa0b97c4a189525932d8530e363
Source dataset
uspto-grants-2013_03
Patent number
US08399682B2

Reaction notes

Loading…