Diisopropylethylamine → HCID 44230250, compound

Participants

Reaction Steps

The preparation of the title compound takes place starting from the compound of Example 112A using 3.2 equivalents of N,N-diisopropylethylamine and with the addition of 0.1% formic acid in the preparative HPLC in analogy to the synthesis of the compound of Example 23. In order to remove the 1,1′,1″-phosphoryltripyrrolidine the product is taken up in a little tetrahydrofuran, water is added to the mixture until a precipitate forms, the tetrahydrofuran is removed in vacuo, and the precipitate is collected by suction filtration, and dried under high vacuum. 25 mg (48% of theory) of the title compound are obtained.

Provenance & Evidence