4-Chloro-2-(trifluoromethyl)benzyl bromide → 1-(4-chloro-2-(trifluoromethyl)benzyl)-1H-indazole-5-carbaldehyde

HRID 1949345Notes

Reaction equation

HRID 1949345 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][C:6]([CH:10]=[O:11])=[CH:7][CH:8]=2)[CH:3]=[N:2]1.Br[CH2:13][C:14]1[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][C:15]=1[C:21]([F:24])([F:23])[F:22]>>[Cl:20][C:17]1[CH:18]=[CH:19][C:14]([CH2:13][N:1]2[C:9]3[C:4](=[CH:5][C:6]([CH:10]=[O:11])=[CH:7][CH:8]=3)[CH:3]=[N:2]2)=[C:15]([C:21]([F:22])([F:23])[F:24])[CH:16]=1

Participants

3

Reactant 2

HCID 34925974-Chloro-2-(trifluoromethyl)benzyl bromideHCID 212506441H-Indazole-5-carboxaldehyde

Product 1

HCID 866545471-(4-chloro-2-(trifluoromethyl)benzyl)-1H-indazole-5-carbaldehyde

Procedure

1-(4-Chloro-2-trifluoromethyl-benzyl)-1H-indazole-5-carbaldehyde was prepared from 1H-indazole-5-carbaldehyde and 1-bromomethyl-4-chloro-2-trifluoromethyl-benzene following General Procedure A.

Sources & evidence

ORD record
ord-4ed11c5326454336b2815be231c6a54c
Source dataset
uspto-grants-2013_03
Patent number
US08399681B2

Reaction notes

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