Sodium borohydride → HCID 67240522, compound

HRID 1949353Notes

Reaction equation

HRID 1949353 reaction equation
[CH3:1][S:2][C:3]1[CH:10]=[CH:9][C:6]([CH:7]=[O:8])=[C:5]([C:11]([F:14])([F:13])[F:12])[CH:4]=1.[BH4-].[Na+]>CO>[CH3:1][S:2][C:3]1[CH:10]=[CH:9][C:6]([CH2:7][OH:8])=[C:5]([C:11]([F:12])([F:13])[F:14])[CH:4]=1

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 81647511HCID 81647511, compound

Product 1

HCID 67240522HCID 67240522, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

4-Methylsulfanyl-2-trifluoromethyl-benzaldehyde (4.87 mmol) was dissolved in 5 mL of MeOH and the resulting solution was treated with NaBH4 (221.1 mg, 5.84 mmol). The reaction mixture was stirred at room temperature for 2 h. The solvent was evaporated and the residue was partitioned between CH2Cl2 and 1N HCl solution. The combined extracts were washed with brine, dried over Na2SO4. A small portion of extracts was evaporated to afford the desired product.

Workup

  1. customThe solvent was evaporated
  2. customthe residue was partitioned between CH2Cl2 and 1N HCl solution
  3. washThe combined extracts were washed with brine
  4. dry with materialdried over Na2SO4
  5. customA small portion of extracts was evaporated

Sources & evidence

ORD record
ord-9e4e504ff26c445aa8d96fa293706f09
Source dataset
uspto-grants-2013_03
Patent number
US08399681B2

Reaction notes

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