反应详情

(4-Methanesulfonyl-2-trifluoromethyl-phenyl)-methanol (4.87 mmol) was dissolved in 40 mL of CH2Cl2 and the resulting solution was treated with PBr3 (1 N, 4.87 mL) at 0° C. for 4 h. The mixture was partitioned between CH2Cl2 and water. The combined CH2Cl2 extracts were washed with brine, dried and evaporated. The residue was purified by flash column chromatography on silica gel (heptane/EtOAc 3:1 v/v) to afford white crystals (1.24 g, 80%).

1. customThe mixture was partitioned between CH2Cl2 and water
2. washThe combined CH2Cl2 extracts were washed with brine
3. customdried
4. customevaporated
5. customThe residue was purified by flash column chromatography on silica gel (heptane/EtOAc 3:1 v/v)