1H-Indazole-5-carboxaldehyde → 1-(4-Methanesulfonyl-2-trifluoromethyl-benzyl)-1H-indazole-5-carbaldehyde

HRID 1949355Notes

Reaction equation

HRID 1949355 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][C:6]([CH:10]=[O:11])=[CH:7][CH:8]=2)[CH:3]=[N:2]1.Br[CH2:13][C:14]1[CH:19]=[CH:18][C:17]([S:20]([CH3:23])(=[O:22])=[O:21])=[CH:16][C:15]=1[C:24]([F:27])([F:26])[F:25]>>[CH3:23][S:20]([C:17]1[CH:18]=[CH:19][C:14]([CH2:13][N:1]2[C:9]3[C:4](=[CH:5][C:6]([CH:10]=[O:11])=[CH:7][CH:8]=3)[CH:3]=[N:2]2)=[C:15]([C:24]([F:25])([F:27])[F:26])[CH:16]=1)(=[O:22])=[O:21]

Participants

3

Reactant 2

HCID 212506441H-Indazole-5-carboxaldehydeHCID 513420492-(Bromomethyl)-5-(methylsulphonyl)benzotrifluoride

Product 1

HCID 866545501-(4-Methanesulfonyl-2-trifluoromethyl-benzyl)-1H-indazole-5-carbaldehyde

Procedure

1-(4-Methanesulfonyl-2-trifluoromethyl-benzyl)-1H-indazole-5-carbaldehyde was prepared from 1H-indazole-5-carbaldehyde and 1-bromomethyl-4-methanesulfonyl-2-trifluoromethyl-benzene following General Procedure A.

Sources & evidence

ORD record
ord-684a14b6118e4e0eae8563e66a0cd1d5
Source dataset
uspto-grants-2013_03
Patent number
US08399681B2

Reaction notes

Loading…