Sodium Hydroxide → HCID 67242073, compound

Participants

Reaction Conditions

Reaction Steps

4-{5-[2-(4-Methyl-piperazin-1-yl)-4-oxo-4H-thiazol-5-ylidenemethyl]-indazol-1-ylmethyl}-3-trifluoromethyl-benzonitrile (Example 10) (15.2 mg, 0.03 mmol) was dissolved in 1 mL of concentrated HCl and the mixture was stirred at 45° C. for 5 h. It was neutralized with aqueous 2N NaOH and extracted with EtOAc. The EtOAc layer was dried over Na2SO4, filtered, and the solvent evaporated in vacuo to yield the desired product (10.8 mg, 68% yield).

Provenance & Evidence