Methanesulfonyl chloride → HCID 76756356, compound

Participants

Reaction Steps

To a solution of 5-[1-(4-hydroxy-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-(4-methyl-piperazin-1-yl)-thiazol-4-one (10 mg, 0.02 mmol) in 1 mL CH2Cl2 was added DIEA (7.7 mg, 0.06 mmol) and methanesulfonyl chloride (4 mg, 0.03 mmol). The mixture was stirred for 1 h and loaded onto a silica gel-packed column. The desired product was eluted with 0-100% gradient of CH2Cl2/EtOAc, followed by 10% MeOH/EtOAc (8.6 mg, 74%).

Provenance & Evidence