L-Azetidine-2-carboxylic acid → HCID 67239765, compound

HRID 1949391Notes

Reaction equation

HRID 1949391 reaction equation
[CH3:1][O:2][C:3]1[CH:27]=[CH:26][C:6]([CH2:7][N:8]2[C:16]3[C:11](=[CH:12][C:13]([CH:17]=[C:18]4[S:22][C:21](SC)=[N:20][C:19]4=[O:25])=[CH:14][CH:15]=3)[CH:10]=[N:9]2)=[C:5]([C:28]([F:31])([F:30])[F:29])[CH:4]=1.[NH:32]1[CH2:35][CH2:34][C@H:33]1[C:36]([OH:38])=[O:37]>>[CH3:1][O:2][C:3]1[CH:27]=[CH:26][C:6]([CH2:7][N:8]2[C:16]3[C:11](=[CH:12][C:13]([CH:17]=[C:18]4[S:22][C:21]([N:32]5[CH2:35][CH2:34][C@H:33]5[C:36]([OH:38])=[O:37])=[N:20][C:19]4=[O:25])=[CH:14][CH:15]=3)[CH:10]=[N:9]2)=[C:5]([C:28]([F:29])([F:30])[F:31])[CH:4]=1

Participants

3

Reactant 2

HCID 16486L-Azetidine-2-carboxylic acidHCID 672406575-[1-(4-methoxy-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-methylsulfanyl-thiazol-4-one

Product 1

HCID 67239765HCID 67239765, compound

Procedure

1-{5-[1-(4-Methoxy-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-4-oxo-4,5-dihydro-thiazol-2-yl}-azetidine-2-(S)-carboxylic acid was prepared from 5-[1-(4-methoxy-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-methylsulfanyl-thiazol-4-one and azetidine-2-(S)-carboxylic acid following General Procedure C.

Sources & evidence

ORD record
ord-1bfd4922814743ccbd9447b247719921
Source dataset
uspto-grants-2013_03
Patent number
US08399681B2

Reaction notes

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