tert-butyl N-[(3S)-piperidin-3-yl]carbamate → HCID 67240791, compound

HRID 1949392Notes

Reaction equation

HRID 1949392 reaction equation
[CH3:1][O:2][C:3]1[CH:27]=[CH:26][C:6]([CH2:7][N:8]2[C:16]3[C:11](=[CH:12][C:13]([CH:17]=[C:18]4[S:22][C:21](SC)=[N:20][C:19]4=[O:25])=[CH:14][CH:15]=3)[CH:10]=[N:9]2)=[C:5]([C:28]([F:31])([F:30])[F:29])[CH:4]=1.[C:32]([O:36][C:37](=[O:45])[NH:38][C@H:39]1[CH2:44][CH2:43][CH2:42][NH:41][CH2:40]1)([CH3:35])([CH3:34])[CH3:33]>>[C:32]([O:36][C:37](=[O:45])[NH:38][CH:39]1[CH2:44][CH2:43][CH2:42][N:41]([C:21]2[S:22][C:18](=[CH:17][C:13]3[CH:12]=[C:11]4[C:16](=[CH:15][CH:14]=3)[N:8]([CH2:7][C:6]3[CH:26]=[CH:27][C:3]([O:2][CH3:1])=[CH:4][C:5]=3[C:28]([F:31])([F:29])[F:30])[N:9]=[CH:10]4)[C:19](=[O:25])[N:20]=2)[CH2:40]1)([CH3:35])([CH3:33])[CH3:34].[NH2:38][C@H:39]1[CH2:44][CH2:43][CH2:42][N:41]([C:21]2[S:22][C:18](=[CH:17][C:13]3[CH:12]=[C:11]4[C:16](=[CH:15][CH:14]=3)[N:8]([CH2:7][C:6]3[CH:26]=[CH:27][C:3]([O:2][CH3:1])=[CH:4][C:5]=3[C:28]([F:30])([F:31])[F:29])[N:9]=[CH:10]4)[C:19](=[O:25])[N:20]=2)[CH2:40]1

Participants

4

Reactant 2

HCID 1514171tert-butyl N-[(3S)-piperidin-3-yl]carbamateHCID 672406575-[1-(4-methoxy-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-methylsulfanyl-thiazol-4-one

Product 2

HCID 67240791HCID 67240791, compoundHCID 67240896HCID 67240896, compound

Procedure

(1-{5-[1-(4-Methoxy-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-4-oxo-4,5-dihydro-thiazol-2-yl}-piperidin-3-yl)-carbamic acid tert-butyl ester was prepared from 5-[1-(4-methoxy-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-methylsulfanyl-thiazol-4-one and piperidin-3-(S)-yl-carbamic acid tert-butyl ester following General Procedure C. The compound was used directly following General Procedure H to provide 2-(3-(S)-Amino-piperidin-1-yl)-5-[1-(4-methoxy-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-thiazol-4-one.

Sources & evidence

ORD record
ord-665cdf5c564549a1a3e86cbb5280a388
Source dataset
uspto-grants-2013_03
Patent number
US08399681B2

Reaction notes

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