HuagongsheHuagongshe Chemistry Print Report · For research reference only
(R)-1-Boc-3-methylpiperazine → HCID 67240689, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (R)-1-Boc-3-methylpiperazine | HCID 2756811 | — |
| Reactant | 5-[1-(4-chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-ethylsulfanyl-thiazol-4-one | HCID 67240123 | — |
| Product | HCID 67240689 | HCID 67240689 | — |
| Product | HCID 67241280 | HCID 67241280 | — |
Reaction Steps
4-{5-[1-(4-Chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-4-oxo-4,5-dihydro-thiazol-2-yl}-3-methyl-piperazine-1-carboxylic acid tert-butyl ester was prepared from 5-[1-(4-chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-ethylsulfanyl-thiazol-4-one and 3-(R)-methyl-piperazine-1-carboxylic acid tert-butyl ester following General Procedure C. The compound was used directly following General Procedure H to provide 5-[1-(4-Chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-(2-(R)-methyl-piperazin-1-yl)thiazol-4-one.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08399681B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-781e9d0eae0e4d05a2961f3bb03e0321 |
| Source note | uspto-grants-2013_03 |