HCID 63909604, compound → HCID 67239647, compound

HRID 1949423Notes

Reaction equation

HRID 1949423 reaction equation
[Cl:1][C:2]1[CH:27]=[CH:26][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([CH:16]=[C:17]4[S:21][C:20](SCC)=[N:19][C:18]4=[O:25])=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[C:4]([C:28]([F:31])([F:30])[F:29])[CH:3]=1.[CH3:32][CH:33]1[CH2:38][NH:37][CH2:36][CH:35]([CH3:39])[N:34]1[C:40](=[O:44])[CH2:41][O:42][CH3:43]>>[Cl:1][C:2]1[CH:27]=[CH:26][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([CH:16]=[C:17]4[S:21][C:20]([N:37]5[CH2:38][C@H:33]([CH3:32])[N:34]([C:40](=[O:44])[CH2:41][O:42][CH3:43])[C@H:35]([CH3:39])[CH2:36]5)=[N:19][C:18]4=[O:25])=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[C:4]([C:28]([F:31])([F:30])[F:29])[CH:3]=1

Participants

3

Reactant 2

HCID 63909604HCID 63909604, compoundHCID 672401235-[1-(4-chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-ethylsulfanyl-thiazol-4-one

Product 1

HCID 67239647HCID 67239647, compound

Procedure

5-[1-(4-Chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-[4-(2-methoxy-acetyl)-cis-3,5-dimethyl-piperazin-1-yl]-thiazol-4-one one was prepared from 5-[1-(4-chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-ethylsulfanyl-thiazol-4-one and 1-(2,6-dimethyl-piperazin-1-yl)-2-methoxy-ethanone following General Procedure C.

Sources & evidence

ORD record
ord-ae11223998524ea4956e3944b4b6d504
Source dataset
uspto-grants-2013_03
Patent number
US08399681B2

Reaction notes

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