1-(Bromomethyl)-4-chloro-2-iodobenzene → 1-(4-Chloro-2-iodo-benzyl)-1H-indazole-5-carbaldehyde

HRID 1949430Notes

Reaction equation

HRID 1949430 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][C:6]([CH:10]=[O:11])=[CH:7][CH:8]=2)[CH:3]=[N:2]1.Br[CH2:13][C:14]1[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][C:15]=1[I:21]>>[Cl:20][C:17]1[CH:18]=[CH:19][C:14]([CH2:13][N:1]2[C:9]3[C:4](=[CH:5][C:6]([CH:10]=[O:11])=[CH:7][CH:8]=3)[CH:3]=[N:2]2)=[C:15]([I:21])[CH:16]=1

Participants

3

Reactant 2

HCID 129309611-(Bromomethyl)-4-chloro-2-iodobenzeneHCID 212506441H-Indazole-5-carboxaldehyde

Product 1

HCID 866545761-(4-Chloro-2-iodo-benzyl)-1H-indazole-5-carbaldehyde

Procedure

1-(4-Chloro-2-iodo-benzyl)-1H-indazole-5-carbaldehyde was prepared from 1H-indazole-5-carbaldehyde and 1-Bromomethyl-4-chloro-2-iodo-benzene following General Procedure A.

Sources & evidence

ORD record
ord-5464e2b53d2f4e99a05b4b5e551fbfa5
Source dataset
uspto-grants-2013_03
Patent number
US08399681B2

Reaction notes

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