2,2,2-TRIFLUOROETHYL CHLOROFORMATE → HCID 76756307, compound

HRID 1949463Notes

Reaction equation

HRID 1949463 reaction equation
[Cl:1][C:2]1[CH:31]=[CH:30][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([CH:16]=[C:17]4[S:21][C:20]([N:22]5[CH2:28][CH2:27][CH2:26][NH:25][CH2:24][CH2:23]5)=[N:19][C:18]4=[O:29])=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[C:4]([C:32]([F:35])([F:34])[F:33])[CH:3]=1.Cl[C:37]([O:39][CH2:40][C:41]([F:44])([F:43])[F:42])=[O:38]>>[F:42][C:41]([F:44])([F:43])[CH2:40][O:39][C:37]([N:25]1[CH2:26][CH2:27][CH2:28][N:22]([C:20]2[S:21][C:17](=[CH:16][C:12]3[CH:11]=[C:10]4[C:15](=[CH:14][CH:13]=3)[N:7]([CH2:6][C:5]3[CH:30]=[CH:31][C:2]([Cl:1])=[CH:3][C:4]=3[C:32]([F:35])([F:34])[F:33])[N:8]=[CH:9]4)[C:18](=[O:29])[N:19]=2)[CH2:23][CH2:24]1)=[O:38]

Participants

3

Reactant 2

HCID 27696482,2,2-TRIFLUOROETHYL CHLOROFORMATEHCID 67240905HCID 67240905, compound

Product 1

HCID 76756307HCID 76756307, compound

Procedure

4-{5-[1-(4-Chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-4-oxo-4,5-dihydro-thiazol-2-yl}-[1,4]diazepane-1-carboxylic acid 2,2,2-trifluoro-ethyl ester was prepared from 5-[1-(4-Chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-[1,4]diazepan-1-yl-thiazol-4-one and 2,2,2-Trifluoroethyl chloroformate according to Example 133.

Sources & evidence

ORD record
ord-cb0e9a6bfbfb47d2a4e7e19175309ff3
Source dataset
uspto-grants-2013_03
Patent number
US08399681B2

Reaction notes

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